2021-03-23

PSMA-617 Lu-177 | C49H68LuN9O16 | CID 122706785 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological

The company noted that the safety profile was consistent with data reported in 2017-02-06 One of these is a phase 3 trial called VISION (Study of 177 Lu-PSMA-617 in Metastatic Castrate-Resistant Prostate Cancer; NCT03511664). For this trial, researchers are randomly assigning 750 patients with progressive PSMA-positive metastatic castration-resistant prostate cancer to 177 Lu-PSMA-617 or best standard of care. We saw recently (see this link) that of chemo and hormonal medicines for metastatic castration-resistant prostate cancer (mCRPC), Jevtana (cabazitaxel) is the preferred third treatment after Taxotere (docetaxel) and Zytiga (abiraterone) or Xtandi (enzalutamide).But when should radiopharmaceuticals, either approved ones like Xofigo (Ra-223), or prospective ones like Lu-177-PSMA-617, be used in 2018-10-18 2021-03-23 If [the VISION study] is positive, then Lu-PSMA-617 could have a considerable impact on care for that space. What other agents are emerging in prostate cancer?

2021-03-23 2021-03-23 2021-02-27 2017-10-05 Endocyte has commenced a Phase III trial, VISION, to evaluate its Lu-PSMA-617 as a third-line treatment in patients suffering from progressive prostate-specific membrane antigen (PSA)-positive About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of (177) Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6 weeks for a maximum of 6 cycles) plus investigator-chosen best standard of care in the investigational arm, versus best standard of care in the control arm(1) (7) . PSMA-617 Lu-177 | C49H68LuN9O16 | CID 122706785 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological 177 Lu‐PSMA‐617 offers a potential additional life‐prolonging treatment option for men with mCRPC. The results of this trial will determine, for the first time in a randomized design, the activity and safety of 177 Lu‐PSMA‐617, as compared with cabazitaxel chemotherapy in men with progressive mCRPC. 2021-03-23 Swiss drug major Novartis AG announced Tuesday positive result from its phase III VISION study evaluating the efficacy and safety of radioligand therapy 177Lu-PSMA-617 in patients with advanced prostate cancer.The trial met both primary endpoints of overall survival and radiographic progression-free survival. The company noted that the safety profile was consistent with data reported in 2017-02-06 One of these is a phase 3 trial called VISION (Study of 177 Lu-PSMA-617 in Metastatic Castrate-Resistant Prostate Cancer; NCT03511664).

In line with the promising initial results of [ 177 Lu]Lu-PSMA-617 therapy, the VISION study is expected to be positive. If indeed so, [ 177 Lu]Lu-PSMA-617 therapy will soon be implemented in daily clinical care in The Netherlands.

4 413. 2 500. 177Lu-DOTATATE peptide receptor radionuclide therapy: dose response in small intestinal Ingår i Journal of Mathematical Imaging and Vision, s.

2018-10-18 · 177 Lu-PSMA-617 is currently being investigated in the Phase III global VISION clinical trial in men with mCRPC, a disease with limited treatment options and significant unmet medical need. If completed, the Endocyte acquisition would expand the Novartis RLT platform with both a potential near-term product launch and early-stage clinical development programs.

doi: 10.1007/s00259-020-04703-3. [Epub ahead of print] Radioligand therapy using [177Lu]Lu-PSMA-617 in mCRPC: a pre-VISION single-center analysis. 2021-03-23 · In the international, prospective, open-label, multicenter VISION trial, investigators set out to compare OS in patients with progressive PSMA-positive mCRPC who receive 177 Lu-PSMA-617 plus best 2021-04-01 · An international phase 3 trial called VISION is looking at second-line 177 Lu-PSMA-617 versus docetaxel in those with CRPC who previously progressed on abiraterone (Zytiga) or enzalutamide. Azad says that 177 Lu-PSMA-617 has shown efficacy in metastatic CRPC in late-stage disease, and there are more data coming out in that area. DOI: 10.1007/s00259-020-04703-3 Corpus ID: 211127815. Radioligand therapy using [177Lu]Lu-PSMA-617 in mCRPC: a pre-VISION single-center analysis @article{Seifert2020RadioligandTU, title={Radioligand therapy using [177Lu]Lu-PSMA-617 in mCRPC: a pre-VISION single-center analysis}, author={R.

[Epub ahead of print] Radioligand therapy using [177Lu]Lu-PSMA-617 in mCRPC: a pre-VISION single-center analysis. 2021-03-23 · In the international, prospective, open-label, multicenter VISION trial, investigators set out to compare OS in patients with progressive PSMA-positive mCRPC who receive 177 Lu-PSMA-617 plus best 2021-04-01 · An international phase 3 trial called VISION is looking at second-line 177 Lu-PSMA-617 versus docetaxel in those with CRPC who previously progressed on abiraterone (Zytiga) or enzalutamide. Azad says that 177 Lu-PSMA-617 has shown efficacy in metastatic CRPC in late-stage disease, and there are more data coming out in that area. DOI: 10.1007/s00259-020-04703-3 Corpus ID: 211127815.

Lu-177-PSMA-617 had a PSA50 of 66% vs 37% for Jevtana; The percent who had PSA progression was 31% less in those getting Lu-177-PSMA-617 relative to those getting Jevtana 2017-10-05 · Endocyte announced it will move PSMA-617 quickly into Phase 3 development in prostate cancer after it licensed the compound from German ABX. The trial, for which the company has yet to seek approval, likely will launch by early 2018.
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Kabasakal et al. Pre-therapeutic dosimetry of normal organs and tissues of (177)Lu-PSMA-617 prostate-specific membrane antigen (PSMA) inhibitor in patients with castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2015 Dec;42(13):1976-83 Radioligand Therapy using 177Lu-PSMA-617 Dosimetry

Basel, March, 23, 2021— Novartis today reported the first interpretable results of the Phase III VISION study evaluating the efficacy and safety of 177Lu-PSMA-617, a targeted radioligand therapy in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) compared to best standard of care alone. Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer (VISION) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.